What is Adipotide?

Adipotide is a synthetic peptide that possesses anti-obesity properties. this peptide particularly targets and destroys specific proteins that constitute the surface of blood vessels that support white fat (adipose) tissue hence interfering with the supply of blood to the fat cells and resulting in their adoptosis (reabsorption and metabolization). Adipotide, aka FTPP or Fat Targeted Proapoptotic Peptide, is a man-made peptidomimetic compound.

Adipotide was initially referred to as Prohibitin-TP01 (Prohibitin-Targeting Peptide 1). It is a peptidomimetic that was synthesized by American scientists as a potential therapeutic drug for obesity and its amino acid sequence is CKGGRAKDC-GG-D(KLAKLAK)2.

Adipotide has been shown to bring about rapid weight loss in both mice and rhesus monkeys. In general, Adipotide has been observed to bring about weight loss by reducing fat tissue especially in the abdominal region), rapid metabolic changes, and decreased food intake.

Adipotide is a new drug that is showing some promise in the area of obesity research. This drug was initially created as a cancer treatment designed to starve cancer cells of a blood supply so they would stop growing.

The effects of Adipotide have shown that the drug actually starves fat cells of blood forcing them to die and be reabsorbed into the body. Initial tests were done on rats and then moved on to monkeys.

The results from testing on rats showed a 30 percent decrease in body weight. After four weeks of daily injections of Adipotide followed by four weeks of non-treatment, 10 obese female rhesus monkeys lost an average of 11 percent of their body weight and 39 percent of fat deposits. Most of the loss was experienced during the non-treatment period.

Some of the main negative side effects to this drug included dehydration and small kidney lesions, which left untreated could lead to kidney failure. Once the drug was discontinued, these problems disappeared.

However, as the drug progresses to human clinical trials, these side effects will need to be dealt with. Adipotide is still a long way from being available for purchase, but the initial studies do make it sound promising.

How Does Adipotide Work?

Research has found that the way this peptide acts has to do with the discriminatory killing of cells in the blood vessels that feed white adipose tissue. Adipotide leads to the vessels’ shrinkage (atrophy) and inevitably the death of cells (apoptosis), thus, cutting off the blood supply to adipocytes.

This, then, leads to insufficient or no oxygen and blood supply (ischemic injury) to the adipocytes. Since the impact is not reversible, the death of fat cells is also inevitable.

Adipotide for weight loss

These data below were published in the peer-reviewed journal Science Translational Medicine in November 2011.

Multiple independent studies with Adipotide have demonstrated that obese rodents lose up to 30% of their body weight after only 28 days of treatment while lean animals show no weight loss.

Studies have also shown that obese animals undergo rapid improvement in pro-diabetic metabolic markers, including significantly improved insulin sensitivity, improved glucose tolerance, and a reduction in serum triglycerides after only 2-3 days of treatment.

Adipotide has been further studied in non-human primates, and it has been reported that after 28 days of treatment obese rhesus monkeys lost an average of 11% of their body weight, experienced a reduction in body mass index and abdominal circumference, and showed marked improvements in insulin resistance, a marker for type II diabetes.

Adipotide Side Effects

One of these adipotide side effects includes wounds of the small kidney that could lead to kidney failure if left untreated. The other noted side effect was dehydration.

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The Adipotide peptides for sale online research only.

References:

[1] https://physoc.onlinelibrary.wiley.com/doi/full/10.14814/phy2.14171

[2] https://www.fiercebiotech.com/biotech/arrowhead-announces-dosing-of-first-patient-anti-obesity-treatment-adipotide%C2%AE-a-phase-1

[3] https://www.cell.com/article/s1550-4131(15)00061-3/abs

[4] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801219/

[5] Barnhart, K. F., Christianson, D. R., Hanley, P. W., … & Pasqualini, R. A peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys. Science translational medicine, 2011.

[6] Kolonin, M. G., Saha, P. K., Chan, L., Pasqualini, R., & Arap, W. Reversal of obesity by targeted ablation of adipose tissue. Nature medicine, 2004.

[7] Staquicini, F. I., Cardó-Vila, M., Kolonin, M. G., … & Arap, W. Vascular ligand-receptor mapping by direct combinatorial selection in cancer patients. Proceedings of the National Academy of Sciences, 2011.

[8] Sci Trans Med 3, 108-112 (2011) DOI: 10.1126/scitraslmed.3002621